Current surgical management of glioblastoma

Cancer J. Mar-Apr 2003;9(2):113-25. doi: 10.1097/00130404-200303000-00007.


Surgical resection is a critical aspect of the management of a patient with a glioblastoma (GBM). An intimate knowledge of the anatomy of a GBM, as well as familiarity with particular surgical techniques and adjunctive technologies is required for safe surgical resection. The goals of resection include diagnosis, relief of mass effect, and cytoreduction. A recent study showed that resection of 98% or more of the tumor mass can result in a statistically significant survival advantage. Even in functionally critical areas, "gross total" resections are possible if proper techniques are employed. It is recommended that a "gross total" resection of the enhancing portion of a GBM be performed whenever possible. With this philosophy, the mortality rate is 3% and the rate of major neurologic morbidity is less than 10%.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Mapping
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery*
  • Glioblastoma / pathology
  • Glioblastoma / surgery*
  • Humans
  • Neurosurgical Procedures / methods*
  • Patient Selection
  • Surgery, Computer-Assisted / methods
  • Survival Analysis