Erosion-inhibiting effect of sodium fluoride and titanium tetrafluoride treatment in vitro

Eur J Oral Sci. 2003 Jun;111(3):253-7. doi: 10.1034/j.1600-0722.2003.00031.x.


The prevention of dental erosion with fluoride is still largely unknown territory. It was the aim of this study to determine the erosion-inhibiting effect of topical neutral 1% sodium fluoride (NaF) application and an application of a 4% titanium tetrafluoride (TiF4) solution compared with no treatment. Ten bovine incisors were selected and three enamel samples prepared from each tooth. One sample from each tooth was assigned to one of three experimental groups. The experimental treatments were: no fluoride application (control); 4 min application of neutral 1% NaF gel; and 4 min application of 4% TiF4 solution. All of the specimens were repeatedly exposed to 50 mm citric acid solution containing 0.4 mm CaCl2, and 2.2 mm KH2PO4 at pH 3.0 over four consecutive days. The acid exposure was performed in intervals and the intensity was increased over the days of the experiment. Enamel dissolution was determined by calcium content measurement of the acid solution after exposure, using atomic absorption spectroscopy. A statistically significant erosion-inhibiting effect was found for both NaF and TiF4 treatments compared with the control group from an erosion exposure time of 3 min. The reduction of calcium loss, however, was higher for the TiF4-treated specimens than the NaF-treated. From 16 min of erosion exposure, the erosion-inhibiting effect was significantly stronger in the TiF4 than the NaF group. The relative reduction of calcium loss compared with the control group remained stable for the TiF4 group, whereas for the NaF group the relative reduction decreased with cumulative erosion time. It is concluded that topical TiF4 application provides a potential treatment option in erosion prevention.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Cattle
  • Fluorides / therapeutic use*
  • Fluorides, Topical / therapeutic use*
  • Sodium Fluoride / therapeutic use*
  • Titanium / therapeutic use*
  • Tooth Demineralization / diagnosis
  • Tooth Erosion / prevention & control*


  • Fluorides, Topical
  • Sodium Fluoride
  • Titanium
  • Fluorides
  • titanium tetrafluoride