The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):275-88. doi: 10.1016/s1359-6101(03)00026-1.


Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen-specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / growth & development*
  • Lymphoid Tissue / immunology
  • Lymphotoxin-alpha / deficiency
  • Lymphotoxin-alpha / genetics
  • Lymphotoxin-alpha / physiology*
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / deficiency
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / physiology


  • Lymphotoxin-alpha
  • Tumor Necrosis Factor-alpha