Calcium signalling in lymphocytes

Curr Opin Immunol. 2003 Jun;15(3):299-307. doi: 10.1016/s0952-7915(03)00050-5.


The modulation of intracellular calcium ion concentration, [Ca(2+)](i), is a common signalling mechanism used in many biological systems. B and T lymphocytes rely on Ca(2+) signalling to initiate both developmental and activation programs. Recent data has shed new light on the initiation of this signalling pathway, the connection between the release of intracellular Ca(2+) stores and the influx of extracellular Ca(2+), and the molecular identity of the elusive Ca(2+) release-activated Ca(2+) (CRAC) channel. In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Calcium / metabolism*
  • Calcium Signaling*
  • Cell Communication
  • Humans
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Models, Immunological
  • Oligonucleotide Array Sequence Analysis
  • Receptors, Antigen / physiology
  • Type C Phospholipases / metabolism


  • Receptors, Antigen
  • Type C Phospholipases
  • Calcium