Heterogeneity of CD4(+) and CD8(+) T cells

Curr Opin Immunol. 2003 Jun;15(3):336-42. doi: 10.1016/s0952-7915(03)00037-2.


There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized. More recently it has become apparent that T-cell populations display additional diversity in terms of phenotype, anatomical distribution and effector function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Humans
  • Immunologic Memory
  • T-Lymphocyte Subsets / classification
  • T-Lymphocyte Subsets / immunology*