Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study

J Ethnopharmacol. 2003 Jul;87(1):115-7. doi: 10.1016/s0378-8741(03)00122-3.

Abstract

The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P<0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Aged
  • Biological Availability
  • Blood Glucose / drug effects
  • Capsules
  • Chemistry, Pharmaceutical
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dose-Response Relationship, Drug
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Lagerstroemia / chemistry*
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry
  • Triterpenes / chemistry
  • Triterpenes / therapeutic use*

Substances

  • Blood Glucose
  • Capsules
  • Hypoglycemic Agents
  • Plant Extracts
  • Triterpenes
  • corosolic acid