Optical coherence tomography findings in nicotinic acid maculopathy

Am J Ophthalmol. 2003 Jun;135(6):913-4. doi: 10.1016/s0002-9394(02)02296-1.


Purpose: To report optical coherence tomography findings in nicotinic acid maculopathy.

Design: Observational case report.

Method: The patient was examined with ophthalmoscopy, fluorescein angiography, and optical coherence tomography.

Results: A 71-year-old man presented with bilateral decreased visual acuity with metamorphopsia. Optical coherence tomography demonstrated cystoid spaces in the outer plexiform layer and inner nuclear layer. Fluorescein angiography did not show leakage. Two weeks after stopping the nicotinic acid, the cystoid spaces resolved.

Conclusions: Niacin maculopathy causes cystoid spaces in the inner nuclear and outer plexiform layers that resolve with discontinuation of the drug.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Fluorescein Angiography
  • Humans
  • Hypercholesterolemia / drug therapy
  • Hypolipidemic Agents / adverse effects*
  • Interferometry
  • Light
  • Male
  • Niacin / adverse effects*
  • Ophthalmoscopy
  • Retina / drug effects*
  • Retina / pathology
  • Retinal Diseases / chemically induced*
  • Retinal Diseases / diagnosis
  • Retinal Diseases / physiopathology
  • Tomography
  • Vision Disorders / chemically induced
  • Vision Disorders / diagnosis
  • Vision Disorders / physiopathology
  • Visual Acuity / drug effects


  • Hypolipidemic Agents
  • Niacin