Infection of Macaque Monkeys With a Chimeric Human and Simian Immunodeficiency Virus

J Gen Virol. 1992 Nov;73 ( Pt 11):2983-7. doi: 10.1099/0022-1317-73-11-2983.

Abstract

Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu and env genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Base Sequence
  • Chromosome Mapping
  • Genes, Viral / genetics*
  • Genes, env / genetics
  • Genes, rev / genetics
  • Genes, tat / genetics
  • Genes, vpu / genetics
  • HIV Infections / genetics*
  • HIV Infections / veterinary*
  • Macaca
  • Molecular Sequence Data
  • RNA / genetics*
  • RNA, Viral / genetics
  • Retroviridae / growth & development
  • Simian Acquired Immunodeficiency Syndrome / genetics*

Substances

  • Antibodies, Viral
  • RNA, Viral
  • RNA, recombinant
  • RNA