Piperacillin induced bone marrow suppression: a case report

BMC Clin Pharmacol. 2003 Jun 5:3:2. doi: 10.1186/1472-6904-3-2.


Background: Piperacillin (and piperacillin/tazobactam) is a commonly prescribed antibiotic and is generally considered safe. We report a case of piperacillin induced bone marrow suppression.

Case presentation: A 19-year-old boy was being treated with piperacillin followed by piperacillin/tazobactam for infected pancreatic pseudocyst. After 21 days of treatment, he developed neutropenia and thrombocytopenia. These reversed promptly after stopping piperacillin/tazobactam. The time course of events suggested that piperacillin was the cause of bone marrow suppression in this patient.

Conclusion: Bone marrow suppression is a serious adverse effect of piperacillin, which should be kept in mind while treating patients with this drug.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / adverse effects*
  • Bone Marrow Diseases / chemically induced*
  • Humans
  • Male
  • Piperacillin / adverse effects*


  • Anti-Bacterial Agents
  • Piperacillin