Abstract
The structure of thymidylate synthase complementing protein with substrates dUMP and FAD, presented in this issue of Structure, sheds light on a fascinating new catalytic mechanism, suggests a strategy for the design of new antimicrobial compounds, and highlights the promise of proteomics in medicine.
MeSH terms
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Deoxyuracil Nucleotides / chemistry
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Deoxyuracil Nucleotides / metabolism
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Drug Design
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Flavin-Adenine Dinucleotide / chemistry
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Flavin-Adenine Dinucleotide / metabolism
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Humans
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Molecular Structure
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Thymidylate Synthase / chemistry*
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Thymidylate Synthase / metabolism
Substances
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Deoxyuracil Nucleotides
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Flavin-Adenine Dinucleotide
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2'-deoxyuridylic acid
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Thymidylate Synthase