Complementing thymidylate synthase

Structure. 2003 Jun;11(6):607-8. doi: 10.1016/s0969-2126(03)00101-1.

Abstract

The structure of thymidylate synthase complementing protein with substrates dUMP and FAD, presented in this issue of Structure, sheds light on a fascinating new catalytic mechanism, suggests a strategy for the design of new antimicrobial compounds, and highlights the promise of proteomics in medicine.

Publication types

  • Comment
  • News

MeSH terms

  • Deoxyuracil Nucleotides / chemistry
  • Deoxyuracil Nucleotides / metabolism
  • Drug Design
  • Flavin-Adenine Dinucleotide / chemistry
  • Flavin-Adenine Dinucleotide / metabolism
  • Humans
  • Molecular Structure
  • Thymidylate Synthase / chemistry*
  • Thymidylate Synthase / metabolism

Substances

  • Deoxyuracil Nucleotides
  • Flavin-Adenine Dinucleotide
  • 2'-deoxyuridylic acid
  • Thymidylate Synthase