Regulation by phosphorylation. Yet another twist in the WASP story

Dev Cell. 2003 Jun;4(6):772-3. doi: 10.1016/s1534-5807(03)00166-7.

Abstract

Cell migration and other complex cellular processes involve a variety of signaling molecules and require the integration of multiple signals into a coherent cytoskeletal response. Two papers in the May issue of Molecular Cell now demonstrate that phosphorylation plays a critical role in WASP function as a regulator of Arp2/3-mediated actin polymerization.

MeSH terms

  • Actin-Related Protein 2
  • Actin-Related Protein 3
  • Actins / metabolism
  • Biopolymers / metabolism
  • Cytoskeletal Proteins / metabolism
  • Cytoskeleton / metabolism
  • Humans
  • Models, Biological
  • Phosphorylation*
  • Protein Conformation
  • Proteins / metabolism*
  • Signal Transduction
  • Wiskott-Aldrich Syndrome / genetics
  • Wiskott-Aldrich Syndrome Protein

Substances

  • ACTR2 protein, human
  • ACTR3 protein, human
  • Actin-Related Protein 2
  • Actin-Related Protein 3
  • Actins
  • Biopolymers
  • Cytoskeletal Proteins
  • Proteins
  • WAS protein, human
  • Wiskott-Aldrich Syndrome Protein