Abstract
Cell migration and other complex cellular processes involve a variety of signaling molecules and require the integration of multiple signals into a coherent cytoskeletal response. Two papers in the May issue of Molecular Cell now demonstrate that phosphorylation plays a critical role in WASP function as a regulator of Arp2/3-mediated actin polymerization.
MeSH terms
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins / metabolism
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Biopolymers / metabolism
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Cytoskeletal Proteins / metabolism
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Cytoskeleton / metabolism
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Humans
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Models, Biological
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Phosphorylation*
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Protein Conformation
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Proteins / metabolism*
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Signal Transduction
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Wiskott-Aldrich Syndrome / genetics
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Wiskott-Aldrich Syndrome Protein
Substances
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ACTR2 protein, human
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ACTR3 protein, human
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins
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Biopolymers
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Cytoskeletal Proteins
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Proteins
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WAS protein, human
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Wiskott-Aldrich Syndrome Protein