Use of neural networks for dosage individualisation of erythropoietin in patients with secondary anemia to chronic renal failure

Comput Biol Med. 2003 Jul;33(4):361-73. doi: 10.1016/s0010-4825(02)00065-3.


The external administration of recombinant human erythropoietin is the chosen treatment for those patients with secondary anemia due to chronic renal failure undergoing periodic hemodialysis. The goal is to carry out an individualised prediction of the erythropoietin dosage to be administered. It is justified because of the high cost of this medication, its secondary effects and the phenomenon of potential resistance which some individuals suffer. One hundred and ten patients were included in this study and several factors were collected in order to develop the neural models. Since the results obtained were excellent, an easy-to-use decision-aid computer application was implemented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia / drug therapy*
  • Anemia / etiology
  • Erythropoietin / administration & dosage*
  • Erythropoietin / therapeutic use
  • Humans
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / physiopathology
  • Neural Networks, Computer*
  • Quality of Life
  • Recombinant Proteins


  • Recombinant Proteins
  • Erythropoietin