Placebo controlled study showing therapeutic benefit of iloprost in the treatment of Raynaud's phenomenon

J Rheumatol. 1992 Sep;19(9):1403-6.


Iloprost is a chemically stable analog of prostaglandin I2 showing the same properties as the naturally occurring substance, but with advantages of ease of handling and administration to patients. A double blind within patient comparison of intravenous iloprost and placebo was undertaken in 13 patients with Raynaud's phenomenon severe enough to warrant short term hospitalization for intravenous dilator therapy; thermography was used as one form of assessment. Our results, while showing improvements in frequency of Raynaud's attacks after iloprost compared with placebo, show no significant effects on other variables.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Female
  • Fingers / blood supply
  • Humans
  • Iloprost / administration & dosage
  • Iloprost / adverse effects
  • Iloprost / therapeutic use*
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Raynaud Disease / diagnosis
  • Raynaud Disease / drug therapy*
  • Thermography


  • Iloprost