Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population

Horm Res. 2003;60(1):29-33. doi: 10.1159/000070824.


Aim: To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults.

Methods: Fasting serum concentrations of IL-18, glucose, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterols were measured in 570 apparently healthy adults.

Results: Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index.

Conclusion: IL-18 may be associated with obesity and glucose intolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / physiology
  • Blood Glucose / metabolism*
  • Body Mass Index
  • Data Collection
  • Female
  • Humans
  • Interleukin-18 / blood*
  • Kuwait
  • Lipids / blood*
  • Male
  • Middle Aged
  • Reference Values


  • Blood Glucose
  • Interleukin-18
  • Lipids