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Clinical Trial
, 19 (3), 200-1

The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

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Clinical Trial

The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

Gary J McCleane. Clin J Pain.

Abstract

Aim: To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.

Method: A double-blind, placebo-controlled crossover study of 30 adult subjects.

Results: Mean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.

Conclusion: The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.

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