Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci

J Infect Dis. 2003 Jun 15;187(12):1876-87. doi: 10.1086/375348. Epub 2003 May 29.

Abstract

Epidemiological studies have proposed an association between group A streptococci (GAS) bearing a particular M serological type and pathologic conditions such as streptococcal toxic shock syndrome (STSS). M1 and M3 GAS are isolated from STSS cases more frequently, whereas M4 and M12 GAS are isolated from non-STSS cases more frequently. To investigate whether there is any difference contributing the M-type association among GAS, we compared various virulence traits, including the murine lethality of M4, M12, M1, and M3 GAS clinical isolates, which are not clonally related to one another. Murine lethality, the activities of superantigens, streptolysin O, and nicotinamide adenine dinucleotide glycohydrolase, and the presence of the speA and speC genes were closely associated with M type. These results indicate that M types may serve, in part, as markers for strains/clones with particular profiles of virulence traits and mouse lethality.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Capsules / metabolism
  • Bacterial Proteins / metabolism
  • Exotoxins*
  • Gene Expression Regulation, Bacterial
  • Hemolysin Proteins / metabolism
  • Humans
  • Hyaluronic Acid / metabolism
  • Japan
  • Lethal Dose 50
  • Membrane Proteins / metabolism
  • Mice
  • NAD+ Nucleosidase / metabolism
  • Risk Factors
  • Serotyping
  • Shock, Septic / microbiology
  • Streptococcus pyogenes / classification*
  • Streptococcus pyogenes / genetics
  • Streptococcus pyogenes / isolation & purification
  • Streptococcus pyogenes / pathogenicity*
  • Streptolysins / metabolism
  • Virulence

Substances

  • Bacterial Proteins
  • Exotoxins
  • Hemolysin Proteins
  • Membrane Proteins
  • SpeA protein, Streptococcus pyogenes
  • Streptolysins
  • Hyaluronic Acid
  • NAD+ Nucleosidase