Emerging role of calprotectin in gastroenterology

J Gastroenterol Hepatol. 2003 Jul;18(7):756-62. doi: 10.1046/j.1440-1746.2003.03014.x.


Calprotectin is a calcium and zinc binding protein of the S100 family derived predominantly from neutrophils and monocytes. It is detectable in body fluids and tissue samples and is emerging as a valuable marker in the diagnosis, and the monitoring and determining of the prognosis of commonly encountered gastroenterological conditions. Fecal calprotectin, in particular, has for a long time been regarded as a promising marker of gastrointestinal pathology and has now been established as a routine test in Norway and at several centers in the UK.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis*
  • Gastrointestinal Diseases / diagnosis*
  • Humans
  • Leukocyte L1 Antigen Complex / analysis*
  • Zinc / pharmacology


  • Biomarkers
  • Leukocyte L1 Antigen Complex
  • Zinc