Treatment of peri-implant infections: a literature review

J Clin Periodontol. 2003 Jun;30(6):467-85. doi: 10.1034/j.1600-051x.2003.00296.x.


Objectives: The purpose of the present paper is to review available information on the treatment of peri-implant mucositis and peri-implantitis.

Materials and methods: The results of animal research and human studies are presented. Proposed strategies for the treatment of peri-implantitis presented in the literature are also included.

Results: Most of the information accessible at this time derives from case reports. The reports provide evidence that efforts to reduce the submucosal infection may result in short-term improvements of the peri-implant lesion. They also indicate that regenerative procedures in intrabony peri-implant defects can result in the formation of new bone.

Conclusions: Several uncertainties remain regarding the treatment of peri-implantitis. Properly conducted long-term follow-ups of consecutively treated cases would seem to be a realistic avenue for accumulation of more information. This may assist in establishing the predictability, magnitude and stability of improvements that can be achieved.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Bone Transplantation
  • Dental Implantation, Endosseous / adverse effects
  • Dental Implants / adverse effects*
  • Dental Implants / microbiology
  • Guided Tissue Regeneration, Periodontal
  • Humans
  • Mouth Mucosa
  • Periodontitis / etiology
  • Periodontitis / therapy*
  • Prosthesis-Related Infections / etiology
  • Prosthesis-Related Infections / therapy*
  • Stomatitis / etiology
  • Stomatitis / therapy
  • Subgingival Curettage


  • Anti-Bacterial Agents
  • Dental Implants