Alteration of the striatal dopaminergic system in human narcolepsy

Neurology. 2003 Jun 10;60(11):1817-9. doi: 10.1212/01.wnl.0000069608.84542.46.

Abstract

Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using [123I](N)-(3-iodopropene-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane and [123I](S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R > or = 0.844, p < or = 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.

MeSH terms

  • Aged
  • Benzamides
  • Corpus Striatum / chemistry*
  • Dopamine Plasma Membrane Transport Proteins
  • Female
  • Humans
  • Iodine Radioisotopes
  • Magnetic Resonance Imaging
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins / analysis*
  • Middle Aged
  • Narcolepsy / diagnosis
  • Narcolepsy / metabolism*
  • Nerve Tissue Proteins*
  • Pyrrolidines
  • Receptors, Dopamine D2 / analysis*
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes

Substances

  • Benzamides
  • Dopamine Plasma Membrane Transport Proteins
  • Iodine Radioisotopes
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Pyrrolidines
  • Receptors, Dopamine D2
  • Tropanes
  • N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane
  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide