Abstract
bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between these factors functions to synchronize neurogenesis with neuronal cell type specification.
MeSH terms
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Animals
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Cell Differentiation / genetics*
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Cell Lineage / genetics*
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Helix-Loop-Helix Motifs / genetics
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Homeodomain Proteins / genetics*
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Humans
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LIM-Homeodomain Proteins
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Motor Neurons / cytology
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Motor Neurons / metabolism*
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Spinal Cord / cytology
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Spinal Cord / embryology*
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Spinal Cord / metabolism
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Stem Cells / cytology
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Stem Cells / metabolism*
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Transcription Factors / genetics*
Substances
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Homeodomain Proteins
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LHX1 protein, human
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LIM-Homeodomain Proteins
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Transcription Factors