Evolutionary Change of Predicted Cytotoxic T Cell Epitopes of Dengue Virus

Infect Genet Evol. 2001 Dec;1(2):123-30. doi: 10.1016/s1567-1348(01)00013-2.

Abstract

Peptides bound by human class I major histocompatibility complex molecules and presented to cytotoxic T cells (CTL) were predicted by a computer algorithm, and changes in these predicted CTL epitopes (pCTLE) were reconstructed by maximum parsimony in a phylogeny of complete genotypes of dengue virus, West Nile virus (WNV), and Japanese encephalitis virus (JEV). In a clade including dengue virus serotypes 1 and 3 (D1V and D3V), pCTLE were lost over evolutionary time at a greater rate than new ones were gained. A similar but less pronounced trend was seen in the other dengue serotypes but not in WNV and JEV. The loss of pCTLE predicted to be restricted by HLA-B(*)2705 was particularly pronounced in D1V and D3V. Since dengue is endemic in humans, while WNV and JEV are not, these results are consistent with CTL-driven selection on dengue viruses, particularly, D1V and D3V.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Antigen Presentation
  • Computer Simulation
  • Dengue Virus / chemistry
  • Dengue Virus / genetics
  • Dengue Virus / immunology*
  • Encephalitis Virus, Japanese / genetics
  • Encephalitis Virus, Japanese / immunology
  • Epitopes, T-Lymphocyte / immunology*
  • Evolution, Molecular*
  • HLA Antigens / immunology
  • Humans
  • Phylogeny
  • T-Lymphocytes, Cytotoxic / immunology*
  • West Nile virus / genetics
  • West Nile virus / immunology

Substances

  • Epitopes, T-Lymphocyte
  • HLA Antigens