Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule

Vaccine. 2003 Jun 20;21(21-22):2791-6. doi: 10.1016/s0264-410x(03)00222-6.


The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Body Temperature / immunology*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Enterotoxins / immunology*
  • Fever / chemically induced
  • Humans
  • Immunization Schedule
  • Immunization, Secondary
  • Macaca mulatta
  • Staphylococcal Vaccines / administration & dosage
  • Staphylococcal Vaccines / adverse effects
  • Staphylococcal Vaccines / immunology*
  • Staphylococcus aureus / immunology
  • Superantigens / immunology*
  • Telemetry
  • Time Factors
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects
  • Vaccines, Synthetic / immunology


  • Enterotoxins
  • Staphylococcal Vaccines
  • Superantigens
  • Vaccines, Synthetic
  • enterotoxin B, staphylococcal