Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization

Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.


Objective: Exploration of the possibility that local injury of the endometrium increases the incidence of implantation.

Design: Prospective study.

Setting: Clinical IVF unit.

Patient(s): A group of 134 patients, defined as good responders to hormonal stimulation, who failed to conceive during one or more cycles of IVF and embryo transfer (ET).

Intervention(s): The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 45 of a total of 134 patients.

Main outcome measures: Outcome of IVF-ET treatments.

Result(s): Transfer of a similar number of embryos (3.4 +/- 1.0 and 3.1 +/- 0.9 in the experimental and control patients, respectively) resulted in rates of implantation (27.7% vs. 14.2%, P =.00011), clinical pregnancy (66.7% vs. 30.3%, P =.00009), and live births per ET (48.9% vs. 22.5%, P =.016) that were more than twofold higher in the experimental group as compared to controls.

Conclusion(s): These results suggest that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.

MeSH terms

  • Adult
  • Biopsy
  • Decidua / physiology
  • Embryo Implantation*
  • Embryo Transfer
  • Endometrium / injuries*
  • Endometrium / pathology
  • Female
  • Fertilization in Vitro*
  • Histamine / physiology
  • Humans
  • Middle Aged
  • Pregnancy
  • Prospective Studies


  • Histamine