Smoking and endothelial function

Prog Cardiovasc Dis. 2003 May-Jun;45(6):443-58. doi: 10.1053/pcad.2003.YPCAD13.


The arterial endothelium is a vital homeostatic cell layer responsible for a variety of functions such as thromboresistance, control of vessel tone, and vessel growth. Recent evidence has indicated that both active and passive cigarette smoking are associated with dysfunction of normal endothelial physiology, in a dose dependent and potentially reversible way. Endothelial abnormalities may predispose to the atherogenic and thrombotic problems associated with cigarette smoking.

Publication types

  • Review

MeSH terms

  • Coronary Artery Disease / etiology*
  • Coronary Artery Disease / physiopathology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Smoking / adverse effects*
  • Tobacco Smoke Pollution / adverse effects*


  • Tobacco Smoke Pollution