Matrix metalloproteinases: old dogs with new tricks

Genome Biol. 2003;4(6):216. doi: 10.1186/gb-2003-4-6-216. Epub 2003 May 29.


The matrix metalloproteinase family in humans comprises 23 enzymes, which are involved in many biological processes and diseases. It was previously thought that these enzymes acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Humans
  • Matrix Metalloproteinases / classification*
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / physiology*


  • Matrix Metalloproteinases