The genomics and proteomics of biofilm formation

Genome Biol. 2003;4(6):219. doi: 10.1186/gb-2003-4-6-219. Epub 2003 May 27.


Bacterial communities that are attached to a surface, so-called biofilms, and their inherent resistance to antimicrobial agents are a cause of many persistent and chronic bacterial infections. Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Biofilms / growth & development*
  • Genes, Bacterial / genetics
  • Genome, Bacterial
  • Genomics*
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / growth & development
  • Gram-Positive Bacteria / genetics
  • Gram-Positive Bacteria / growth & development
  • Proteomics*


  • Bacterial Proteins