The diverse functions of histone acetyltransferase complexes

Trends Genet. 2003 Jun;19(6):321-9. doi: 10.1016/S0168-9525(03)00115-X.


Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle progression. The high conservation of the acetyltransferase complexes and their functions illustrates their central role in cell growth and development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / metabolism*
  • Amino Acid Sequence
  • Animals
  • Cell Cycle
  • Cell Division
  • Cell Nucleus / enzymology
  • DNA Repair
  • Gene Silencing
  • Histone Acetyltransferases
  • Histone Deacetylases / metabolism*
  • Histones / metabolism*
  • Humans
  • Molecular Sequence Data
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Transcription, Genetic
  • Transcriptional Activation


  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • Histone Deacetylases