Reversed temporal region asymmetries of P300 topography in left- and right-handed schizophrenic subjects

D P Holinger; S F Faux; M E Shenton; N S Sokol; L J Seidman; A I Green; R W McCarley

doi:10.1016/0168-5597(92)90042-a

Reversed temporal region asymmetries of P300 topography in left- and right-handed schizophrenic subjects

Electroencephalogr Clin Neurophysiol. 1992 Nov-Dec;84(6):532-7. doi: 10.1016/0168-5597(92)90042-a.

Authors

D P Holinger¹, S F Faux, M E Shenton, N S Sokol, L J Seidman, A I Green, R W McCarley

Affiliation

¹ Department of Psychiatry, Harvard Medical School, Brockton VAMC, MA 02401.

PMID: 1280199
DOI: 10.1016/0168-5597(92)90042-a

Abstract

The auditory P300 evoked potential was recorded in 36 subjects: left- (LH) and right-handed (RH) schizophrenic males and LH and RH normal controls. LH and RH normals showed no asymmetry in P300 scalp topography. LH and RH schizophrenics, however, showed lateralized asymmetries in temporal scalp regions: left < right P300 voltage asymmetry in RH schizophrenics and left > right P300 voltage asymmetry in LH schizophrenics. These data suggest that the schizophrenic pathology of P300 neural generators is lateralized according to handedness and provide the first evidence that LH and RH schizophrenics can be dissociated based on left-right voltage asymmetries in P300 topography. These findings further emphasize the need for control of handedness in P300 studies of schizophrenia.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acoustic Stimulation
Adult
Analysis of Variance
Brain Mapping*
Electroencephalography
Evoked Potentials, Auditory / physiology
Functional Laterality / physiology*
Humans
Male
Reaction Time / physiology
Schizophrenia / physiopathology*