Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo

Bull Exp Biol Med. 2003 Feb;135(2):130-2. doi: 10.1023/a:1023855428130.

Abstract

Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging, Premature / metabolism
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Brain / metabolism*
  • Carnosine / administration & dosage
  • Carnosine / pharmacology*
  • Hypoxia / metabolism
  • Lipid Peroxidation
  • Male
  • Mice
  • Oxidative Stress*
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / metabolism*

Substances

  • Antioxidants
  • Carnosine
  • Superoxide Dismutase