Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes

FEBS Lett. 2003 Jun 19;545(2-3):103-4. doi: 10.1016/s0014-5793(03)00568-4.


Low levels of high-density lipoprotein (HDL)-cholesterol represent an independent cardiovascular risk factor and, besides reduced physical activity, mechanisms leading to decreased HDL-cholesterol levels are not known. We aimed to test the hypothesis, that adiponectin provides a missing link between type 2 diabetes and low levels of HDL-cholesterol, independent from common metabolic risk factors. 523 patients with type 2 diabetes were investigated for adiponectin serum levels and parameters of lipid metabolism. Even after correction for age, gender, BMI and fasting insulin concentration, serum levels of adiponectin were highly significant (P<0.0001) and positively (regression analysis: r=0.86) associated with HDL-cholesterol levels in type 2 diabetes.

Conclusion: adiponectin seems to predict HDL-cholesterol levels in patients with diabetes mellitus type 2. Low levels of adiponectin are associated with low levels of HDL-cholesterol independently from common metabolic risk factors and therefore represent an independent cardiovascular risk factor in type 2 diabetes. Thus, adiponectin is a potentially new drug target in the treatment of dyslipidaemia.

Publication types

  • Comparative Study

MeSH terms

  • Adiponectin
  • Body Mass Index
  • Cardiovascular Diseases / blood*
  • Cholesterol, HDL / blood*
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics
  • European Continental Ancestry Group
  • Fasting / blood
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Insulin / blood
  • Intercellular Signaling Peptides and Proteins*
  • Male
  • Predictive Value of Tests
  • Proteins / analysis*
  • Proteins / metabolism
  • Regression Analysis
  • Risk Factors


  • Adiponectin
  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins