Treating depression comorbid with anxiety--results of an open, practice-oriented study with St John's wort WS 5572 and valerian extract in high doses

Phytomedicine. 2003;10 Suppl 4:25-30. doi: 10.1078/1433-187x-00305.


Depressive disorders in comorbidity with anxiety disorders represent an frequently diagnostic and therapeutic problem. The studies quoted here prove that the symptoms associated with anxiety that severely afflict patients can be clearly improved more quickly with a combination therapy of St John's wort extract and valerian extract than with St John's wort monotherapy. The combination therapy was well tolerated, no significant side-effects occurred. Further studies are necessary to compare the combination treatment with other forms of therapy (serotonin- and noradrenalin re-uptake inhibitors).

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / therapeutic use*
  • Anxiety Disorders / complications
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / pathology
  • Comorbidity
  • Depression / complications
  • Depression / drug therapy*
  • Depression / pathology
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Germany
  • Humans
  • Hypericum*
  • Male
  • Manifest Anxiety Scale
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Treatment Outcome
  • Valerian*


  • Antidepressive Agents
  • Plant Extracts
  • WS 5572