Pre-cancerous lesions for colorectal cancers in rodents: a new concept

Carcinogenesis. 2003 Jun;24(6):1015-9. doi: 10.1093/carcin/bgg041. Epub 2003 Mar 28.


It is widely believed that colorectal carcinogenesis is a representative multi-step tumorigenesis with events of genetic alterations. Aberrant crypt foci (ACF) recognized on the surface of cancer-predisposed colons of rodents have been regarded as early-appearing pre-neoplastic lesions. However, it is not clear if such lesions are truly pre-cancerous lesions for colorectal cancers in rodents. Recently, beta-catenin-accumulated crypts (BCAC) were identified in colonic mucosa at the early stages of colon carcinogenesis. Accumulating evidence indicates that they are independent small dysplastic lesions of ACF. Here we discuss the importance of BCAC as pre-cancerous lesions in colon carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Cell Differentiation
  • Colon / pathology
  • Colorectal Neoplasms / pathology*
  • Cytoskeletal Proteins / physiology
  • Genes, APC / physiology
  • Mice
  • Precancerous Conditions / pathology*
  • Trans-Activators / physiology
  • beta Catenin


  • Biomarkers, Tumor
  • CTNNB1 protein, mouse
  • Cytoskeletal Proteins
  • Trans-Activators
  • beta Catenin