False discovery rate in linkage and association genome screens for complex disorders

Genetics. 2003 Jun;164(2):829-33. doi: 10.1093/genetics/164.2.829.


We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bipolar Disorder / genetics
  • Chromosome Mapping
  • Genetic Linkage*
  • Genetic Predisposition to Disease
  • Genetic Testing*
  • Genome
  • Genome, Human
  • Haplotypes
  • Humans
  • Lod Score
  • Models, Genetic*
  • Models, Statistical
  • Normal Distribution
  • Reproducibility of Results