Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 116 (Pt 14), 2823-32

'Eph'ective Signaling: Forward, Reverse and Crosstalk


'Eph'ective Signaling: Forward, Reverse and Crosstalk

Keith K Murai et al. J Cell Sci.


The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in a wide variety of cell types in developing and mature tissues. Their ligands are the ephrins, a family of membrane-bound proteins found in lipid rafts. In the past decade, Eph receptors and ephrins have been implicated in a vast array of cellular processes. Unlike other receptor tyrosine kinases, however, the Eph receptors seem to be geared towards regulating cell shape and movement rather than proliferation. Studies have uncovered intricate signaling networks that center around the ligand-receptor complex, and this may account for the broad repertoire of functions of Eph proteins. Deciphering the bi-directional pathways emanating from an Eph receptor-ephrin complex will not only help us to understand basic biological processes, but may also provide important insight into disease.

Similar articles

See all similar articles

Cited by 101 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources