Nitric oxide as a signal in blood vessels

Trends Biochem Sci. 1992 Oct;17(10):399-402. doi: 10.1016/0968-0004(92)90008-w.


In the five years since the discovery that nitric oxide is produced as a signal in blood vessels, a great deal has been discovered about the processes involved. This article reviews current knowledge about the vascular cell synthesis, effects and subsequent destruction of this messenger molecule.

Publication types

  • Review

MeSH terms

  • Amino Acid Oxidoreductases / metabolism
  • Animals
  • Blood Vessels / physiology*
  • Endothelium, Vascular / enzymology
  • Endothelium, Vascular / physiology
  • Humans
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase
  • Signal Transduction / physiology*
  • Vasodilation / physiology


  • Nitric Oxide
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases