Growth and development in white patients with sickle cell diseases

Am J Pediatr Hematol Oncol. 1992 Nov;14(4):285-8.

Abstract

We have evaluated height, weight, bone age, somatomedin-C levels, and pubertal development in 114 Sicilian patients affected by sickle cell diseases (SCDs). Thirty-one had homozygous sickle hemoglobin (SS), 55 S-beta 0 thalassemia, and 28 S-beta + thalassemia. In both children and adults, the mean height and weight were approximately 1 SD below the normal mean for age. The height was below the normal range only in a few subjects (8 children and 4 adult women). Somatomedin-C levels were within the normal range in most of the patients (37/44 children and 17/22 adults). Bone age revealed a slight delay in skeletal maturation (mean chronological age and bone age were 7.7 +/- 3 and 7.11 +/- 2.9 respectively; p < 0.05). Mean age at menarche was increased compared to normal subjects. Our findings show that Sicilian patients with SCD exhibit a moderate delay of growth and adolescence but attain a final height within the normal range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Developmental Disabilities / etiology*
  • Female
  • Growth Disorders / etiology*
  • Haplotypes
  • Humans
  • Infant
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Middle Aged
  • Sickle Cell Trait / ethnology*
  • Sickle Cell Trait / physiopathology*
  • Whites*

Substances

  • Insulin-Like Growth Factor I