mRNA cap-1 Methyltransferase in the SARS Genome

Cell. 2003 Jun 13;113(6):701-2. doi: 10.1016/s0092-8674(03)00424-0.

Abstract

The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.

Publication types

  • Letter

MeSH terms

  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Genome, Viral*
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Models, Molecular
  • Protein Structure, Tertiary / genetics
  • RNA, Messenger / metabolism*
  • SARS Virus / enzymology*
  • SARS Virus / genetics*
  • Severe Acute Respiratory Syndrome / virology*
  • TNF Receptor-Associated Factor 3
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins*
  • Viral Proteins / genetics*
  • Viral Proteins / metabolism

Substances

  • Carrier Proteins
  • RNA, Messenger
  • TNF Receptor-Associated Factor 3
  • TRAF3 protein, human
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
  • Viral Proteins
  • Methyltransferases