Human leukocyte antigen distribution in Israeli patients with psoriatic arthritis

Rheumatol Int. 2004 Mar;24(2):93-7. doi: 10.1007/s00296-003-0325-0. Epub 2003 Jun 17.


Objectives: This study was designed to investigate the distribution of human leukocyte antigen (HLA) classes I and II in a group of Israeli Jewish patients with psoriatic arthritis (PsA) and identify HLA markers related to disease manifestation in PsA.

Patients and methods: Human leukocyte antigens class I and class II (both serologically and from oligotyping) were tested in a group of 50 consecutive patients with PsA, 32 with skin psoriasis (PSO), and 255 healthy persons. Data on age, gender, disease duration, and pattern of rheumatological manifestations-oligoarthritis, polyarthritis, spinal involvement, involvement of distal interphalangeal joints (DIPs), and enthesitis-were registered.

Results: Human leukocyte antigens A3, B13, and B38 alleles were found to be significantly prevalent in PsA compared with PSO patients and healthy controls. HLA-B27 was found in only two out of 50 patients with PsA. Patients with PSO and PsA had significantly increased incidence of HLA-DRB0101 and -DRB0301, while the frequency of HLA-DRB0403 was significantly higher among patients with PsA of Ashkenazi origin. We found a statistically significant association between DIP involvement and the presence of HLA-A26 and -B38, while HLA-DRB0301 was related to spinal involvement.

Conclusions: Psoriatic arthritis in Israeli patients seems to be associated with the presence of HLA-A3, -B13, -B38, -DRB0101, and -DRB0301. HLA-B27 was not a marker of PsA in this cohort of patients, including patients with psoriatic spondyloarthropathy.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Psoriatic / blood
  • Arthritis, Psoriatic / ethnology
  • Arthritis, Psoriatic / immunology*
  • Biomarkers / blood
  • Cohort Studies
  • Female
  • HLA Antigens / blood
  • HLA Antigens / immunology*
  • Humans
  • Israel
  • Jews / ethnology
  • Male
  • Middle Aged


  • Biomarkers
  • HLA Antigens