Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent?

J Neural Transm (Vienna). 2003 Jul;110(7):707-18. doi: 10.1007/s00702-003-0823-y.

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) has recently been hypothesized to be effective against the symptoms of Parkinson's disease. Therefore we tested the effects of MDMA-derivatives in the rotational behavioural model. Male Sprague Dawley rats were lesioned unilaterally with 6-hydroxydopamine at the medial forebrain bundle. MDMA was administered at doses of 2.5, 5.0 and 10.0 mg/kg, its derivatives N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butananamine (MBDB), 3,4-Methylenedioxy-N-ethylamphetamine (MDE) and 3,4-Methylenedioxyamphetamine (MDA) at 5.0 mg/kg respectively. All substances induced ipsilateral rotations, MDA being the most effective. MDMA induced rotations were attenuated by the selective serotonin reuptake inhibitor Citalopram but were only slightly reduced by pre-treatment with the selective serotonin synthesis inhibitor PCPA (para-chlorophenylalanine). The effects of MDMA can therefore not fully be explained by serotonin release or by dopaminergic activity of the drugs.

Publication types

  • Comparative Study

MeSH terms

  • 3,4-Methylenedioxyamphetamine / analogs & derivatives*
  • 3,4-Methylenedioxyamphetamine / pharmacology
  • Adrenergic Agents / pharmacology
  • Animals
  • Apomorphine / pharmacology
  • Behavior, Animal / drug effects
  • Citalopram / pharmacology
  • Dopamine / metabolism*
  • Fenclonine / pharmacology
  • Functional Laterality
  • Hallucinogens / pharmacology*
  • Male
  • Medial Forebrain Bundle / drug effects*
  • Medial Forebrain Bundle / physiopathology*
  • Models, Animal
  • N-Methyl-3,4-methylenedioxyamphetamine / pharmacology*
  • Oxidopamine / pharmacology
  • Parkinson Disease / physiopathology
  • Rats
  • Rats, Sprague-Dawley
  • Rotation
  • Serotonin Antagonists / pharmacology
  • Serotonin Uptake Inhibitors / pharmacology

Substances

  • Adrenergic Agents
  • Hallucinogens
  • Serotonin Antagonists
  • Serotonin Uptake Inhibitors
  • Citalopram
  • N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine
  • 3,4-Methylenedioxyamphetamine
  • Oxidopamine
  • N-Methyl-3,4-methylenedioxyamphetamine
  • 3,4-methylenedioxyethamphetamine
  • Apomorphine
  • Fenclonine
  • Dopamine