An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain

Oncogene. 1992 Dec;7(12):2499-506.


In search of genes possibly involved in the regulation of hindbrain segmentation, we have isolated mouse cDNA clones corresponding to putative protein kinase genes by polymerase chain reaction amplification of cDNA from 9.5-day-old embryo hindbrains. In situ hybridization analysis revealed that one of these genes, Sek, was expressed in an alternating segment-restricted pattern in the developing hindbrain. Isolation and analysis of Sek cDNAs covering the entire coding sequence indicated that Sek encoded a putative receptor protein tyrosine kinase, belonging to the Eph family. These data are consistent with a role of the Sek gene product in a signal transduction process involved in pattern formation in the hindbrain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Embryo, Mammalian
  • Fetal Proteins / genetics*
  • Gene Expression Regulation, Enzymologic*
  • In Situ Hybridization
  • Membrane Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Oligodeoxyribonucleotides
  • Polymerase Chain Reaction / methods
  • Protein-Tyrosine Kinases / genetics*
  • RNA / genetics
  • RNA / isolation & purification
  • Receptor, EphA4
  • Receptor, EphA8
  • Receptors, Cell Surface / genetics*
  • Rhombencephalon / embryology
  • Rhombencephalon / enzymology*
  • Sequence Homology, Amino Acid


  • Fetal Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Oligodeoxyribonucleotides
  • Receptors, Cell Surface
  • RNA
  • Protein-Tyrosine Kinases
  • Receptor, EphA4
  • Receptor, EphA8

Associated data

  • GENBANK/X57236
  • GENBANK/X57237
  • GENBANK/X57238
  • GENBANK/X57239
  • GENBANK/X57240
  • GENBANK/X57241
  • GENBANK/X57242
  • GENBANK/X57243
  • GENBANK/X57244
  • GENBANK/X65138