Wingless signaling: an axin to grind

Curr Biol. 2003 Jun 17;13(12):R479-81. doi: 10.1016/s0960-9822(03)00407-x.


Negative regulation of Wingless/Wnt signaling plays an important role in embryonic patterning and is also needed for tumor suppression in adult tissues. New findings in Drosophila reveal a novel mechanism for down-regulating the activity of the Wingless/Wnt pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Down-Regulation*
  • Drosophila / embryology*
  • Drosophila Proteins / physiology*
  • Morphogenesis
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction*
  • Wnt1 Protein


  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Wnt1 Protein
  • wg protein, Drosophila