MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea

Genes Dev. 2003 Jun 15;17(12):1469-74. doi: 10.1101/gad.256603.


Shoot branching is inhibited by auxin transported down the stem from the shoot apex. Auxin does not accumulate in inhibited buds and so must act indirectly. We show that mutations in the MAX4 gene of Arabidopsis result in increased and auxin-resistant bud growth. Increased branching in max4 shoots is restored to wild type by grafting to wild-type rootstocks, suggesting that MAX4 is required to produce a mobile branch-inhibiting signal, acting downstream of auxin. A similar role has been proposed for the pea gene, RMS1. Accordingly, MAX4 and RMS1 were found to encode orthologous, auxin-inducible members of the polyene dioxygenase family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / drug effects
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / physiology*
  • Cloning, Molecular
  • DNA Transposable Elements
  • Gene Expression Regulation, Plant*
  • Indoleacetic Acids / pharmacology
  • Mutation
  • Oxygenases / genetics
  • Oxygenases / physiology*
  • Phylogeny
  • Pisum sativum / genetics
  • Plant Roots / genetics
  • Plant Roots / growth & development
  • Plant Shoots / drug effects
  • Plant Shoots / genetics
  • Plant Shoots / physiology*
  • Sequence Homology, Nucleic Acid


  • Arabidopsis Proteins
  • DNA Transposable Elements
  • Indoleacetic Acids
  • MAX4 protein, Arabidopsis
  • Oxygenases
  • RMS1 protein, pea