Graft-versus-tumor effect in a patient with advanced neuroblastoma who received HLA haplo-identical bone marrow transplantation

Bone Marrow Transplant. 2003 Jul;32(1):103-6. doi: 10.1038/sj.bmt.1704070.


A 5-year-old boy received CD34-positive HLA haplo-identical bone marrow transplantation from his father as treatment for refractory advanced neuroblastoma. He had residual disease in the para-aortic lymph nodes and multiple bones after the transplant. However, all of his residual disease had disappeared completely 3 years later. He developed grade I acute graft-versus-host disease (GVHD) but had no symptoms of chronic GVHD or any other complications. This case demonstrates the possibility of a graft-versus-tumor effect against neuroblastoma by HLA-mismatched allogeneic hematopoietic stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation / immunology*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary
  • Child, Preschool
  • Disease-Free Survival
  • Graft vs Host Disease
  • Graft vs Tumor Effect / immunology*
  • Haplotypes
  • Histocompatibility
  • Histocompatibility Testing
  • Humans
  • Male
  • Neoplasm, Residual / diagnosis
  • Neuroblastoma / pathology
  • Neuroblastoma / therapy*
  • Radionuclide Imaging
  • Transplantation, Isogeneic