The pleiotropic functions of the Y-box-binding protein, YB-1

Bioessays. 2003 Jul;25(7):691-8. doi: 10.1002/bies.10300.


The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / genetics
  • CCAAT-Enhancer-Binding Proteins / metabolism*
  • DNA Repair*
  • DNA-Binding Proteins*
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / metabolism
  • Models, Biological
  • NFI Transcription Factors
  • Nuclear Proteins
  • Protein Biosynthesis
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • Vertebrates
  • Y-Box-Binding Protein 1


  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Heat-Shock Proteins
  • NFI Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Y-Box-Binding Protein 1
  • YBX1 protein, human