Association between depressed mood in the elderly and a 5-HTR2A gene variant

Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):79-84. doi: 10.1002/ajmg.b.20016.


The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5-HTR2A gene promotor (-1438 G/A) and one in the 5-HT transporter gene (-925 C/A). DNA from a population-based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing trade mark. An association was found between the 5-HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, CI: 1.1-2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, CI: 1.4-4.4) was found for males and the A/A genotype, but not for females. The 5-HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Twin Study

MeSH terms

  • Aged*
  • Depressive Disorder / etiology
  • Depressive Disorder / genetics*
  • Diseases in Twins / genetics
  • Female
  • Gene Frequency
  • Genetic Variation*
  • Genotype
  • Humans
  • Longitudinal Studies
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Sex Factors
  • Sweden
  • Twins, Dizygotic
  • Twins, Monozygotic