Novel synthesis of heterocycles having a functionalized carbon center via nickel-mediated carboxylation: total synthesis of erythrocarine

Kazuya Shimizu; Masanori Takimoto; Miwako Mori

doi:10.1021/ol034670w

Novel synthesis of heterocycles having a functionalized carbon center via nickel-mediated carboxylation: total synthesis of erythrocarine

Org Lett. 2003 Jun 26;5(13):2323-5. doi: 10.1021/ol034670w.

Authors

Kazuya Shimizu¹, Masanori Takimoto, Miwako Mori

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 12816439
DOI: 10.1021/ol034670w

Abstract

Novel synthetic procedure of heterocycles was developed using nickel-mediated alkylative carboxylation, and the total synthesis of erythrocarine was achieved using this method and RCM of dienyne as the key steps. [reaction: see text]

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkynes / chemistry
Erythrina / chemistry*
Heterocyclic Compounds / chemistry*
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
Nickel / chemistry*

Substances

Alkaloids
Alkynes
Heterocyclic Compounds
Heterocyclic Compounds, 4 or More Rings
erythrocarine
Nickel