The causes and clinical picture of osteopenia and osteoporosis were analyzed in 13 children (7 girls and 6 boys aged 6-15 years of life, mean age 10.2 years). The diagnosis was based on X-ray and densitometric studies. Upper gastrointestinal tract diseases were noted in 7 patients (one child received additional anti-epileptic drugs) and 5 had juvenile osteoporosis. Children with Gl tract diseases and these on anti-epileptic management may develop osteoporosis and osteopenia as a consequence of vitamin D3 deficit and calcium malabsorption leading to hypocalcemia and secondary hyperparathyroidism.