Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry

Vision Res. 2003 Jul;43(16):1765-75. doi: 10.1016/s0042-6989(03)00280-3.


Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7 degrees was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology
  • Fluorescence
  • Humans
  • Macula Lutea / metabolism
  • Macular Degeneration / etiology*
  • Motion Perception / physiology
  • Ophthalmoscopes
  • Photometry / methods
  • Retina / physiology*
  • Retinal Pigments / metabolism


  • Retinal Pigments