Brugada-type electrocardiographic pattern induced by epidural bupivacaine

Anesth Analg. 2003 Jul;97(1):264-7, table of contents. doi: 10.1213/01.ane.0000067410.32384.3a.


In this case report, we describe the postoperative occurrence of electrocardiogram changes suggestive for the Brugada syndrome in a patient receiving a continuous epidural bupivacaine infusion. After withdrawal of bupivacaine, the electrocardiogram changes were reversible. The patient's history was unremarkable except for an incomplete right bundle branch block. We conclude that local anesthetics, particularly bupivacaine, have the potential to induce serious arrhythmias in patients with Brugada syndrome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anesthesia, Epidural / adverse effects*
  • Anesthetics, Local / adverse effects*
  • Arrhythmias, Cardiac / chemically induced*
  • Arrhythmias, Cardiac / physiopathology
  • Blood Pressure
  • Bundle-Branch Block / chemically induced
  • Bundle-Branch Block / physiopathology
  • Bupivacaine / adverse effects*
  • Electrocardiography / drug effects*
  • Exercise Test
  • Gastrectomy
  • Humans
  • Male
  • Stomach Neoplasms / surgery


  • Anesthetics, Local
  • Bupivacaine