Convergent evolution of gene circuits

Nat Genet. 2003 Jul;34(3):264-6. doi: 10.1038/ng1181.


Convergent evolution is a potent indicator of optimal design. We show here that convergent evolution occurs in genetic networks. Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Escherichia coli / genetics*
  • Evolution, Molecular*
  • Feedback / physiology
  • Gene Duplication*
  • Gene Expression Regulation / genetics*
  • Genes, Bacterial / physiology*
  • Genes, Fungal / physiology*
  • Genome, Bacterial
  • Genome, Fungal
  • Models, Genetic
  • Saccharomyces cerevisiae / genetics*
  • Schizosaccharomyces / genetics*
  • Transcription, Genetic / genetics*